LP231891-5     Myelin oligodendrocyte glycoprotein Ab

DESCRIPTION
  Part: Myelin oligodendrocyte glycoprotein Ab
  Description: Myelin oligodendrocyte glycoprotein (MOG) is a protein made up of two polypeptides with molecular masses of 26 and 28 kilodaltons, respectively. MOG is located on the surface of myelin and oligodendrocyte cytoplasmic membranes and binds to the monoclonal antibody 8-18C5. [PMID: 1373175] MOG is a probable autoantigen target associated with multiple sclerosis (MS) and other demyelinating diseases (DD) of the central nervous system. [PMID: 1373175] That being said, there is variation in the level of MOG antibody found in patients with MS and DD with inconsistencies between MOG antibody measurements using western blot and ELISA test methods, making it a questionable biomarker for DD. [PMID: 17294606] MOG IgG1 is the most prevalent isotype of IgG in patients with DD. [PMID: 29063242]
 
 

BASIC PART PROPERTIES
  Construct for LOINC short name: MOG Ab
  Type: COMPONENT
  Status: ACTIVE
  Created On: 10/25/2016

INTERNAL FIELDS
  Detail Page Created On: 6/20/2019 10:42:16 AM
  Display name: Myelin oligodendrocyte glycoprotein Ab
  Preferred Abbreviation: MOG Ab