LP15729-4     Methemoglobin

  Part: Methemoglobin
  Description: Methemoglobin is a form of the oxygen-carrying protein hemoglobin, in which the iron in the heme group is in the Fe3+ state, not the Fe2+ of normal hemoglobin. Metheomglobin appears blue and is unable to carry oxygen. The NADH-dependent enzyme methemoglobin reductase (AKA diaphorase I) is responsible for converting methemoglobin back to hemoglobin. Normally 1-2% of people's hemoglobin is methemoglobin, a higher percentage than this can be genetic or caused by exposure to various chemicals and depending on the level can cause health problems. A higher level of methemoglobin will tend to cause a pulse oximeter to read closer to 85% regardless of the true level of oxygen saturation. Methemoglobinemia can be caused by genetic abnormalities such as diaphorase I deficiency, or abnormal hemoglobin variants. It can also be caused by certain oxidizing drugs (benzocaine), antibiotics (trimethoprim or sulfanamides), analine dyes, metoclopramide, chlorates, bromates, and nitrates. Infants under 6 months are particularly susceptible when exposed to nitrates, benzocaine, or even dehydration. Methemoglobinemia can be treated with supplemental oxygen and methylene blue.
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  Part: Methemoglobin
  Description: Brown pigment formed from hemoglobin by oxidation of the ferrous to the ferric state.

  Construct for LOINC short name: MetHgb
  Status: ACTIVE
  Created On: 5/4/2000

  Chinese (CHINA)  (From: Lin Zhang, A LOINC volunteer from China)   SYNONYMS
  高铁血红蛋白     Hi;MetHb;MetHgb;正铁血红蛋白;氧化血红蛋白
  Dutch (NETHERLANDS)  (From: NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)    
  Estonian (ESTONIA)  (From: Estonian E-Health Foundation)    
  French (BELGIUM)  (From: Jean M. Prevost, MD, Biopathology)    
  French (CANADA)  (From: Canada Health Infoway Inc.)    
  Italian (ITALY)  (From: Consiglio Nazionale delle Ricerche)   SYNONYMS
  Metaemoglobina     Metemoglobina
  Russian (RUSSIAN FEDERATION)  (From: Yaroslavl State Medical Academy)    
  Spanish (SPAIN)  (From: the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)   SYNONYMS
  Metahemoglobina     Hemoglobina
  Turkish (TURKEY)  (From: LOINC Turkish Translation Group and the Turkish Ministry of Health)    

  Detail Page Created On: 6/20/2019 9:33:55 AM
  Display name: Methemoglobin
  Preferred Abbreviation: MetHgb