LP15698-1     Sphingomyelin

DESCRIPTION
  Part: Sphingomyelin
  Description: Sphingomyelin (SPH) is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath that surrounds some nerve cell axons. It usually consists of phosphorylcholine and ceramide. In humans SPH represents ~85% of all sphingolipids.

Sphingomyelin can accumulate in a rare hereditary disease called Niemann-Pick Disease, types A and B. It is a genetically-inherited disease caused by a deficiency in the enzyme Sphingomyelinase, which causes the accumulation of Sphingomyelin in spleen, liver, lungs, bone marrow, and the brain, causing irreversible neurological damage. Of the two types involving Sphingomyelinase, type A occurs in infants. It is characterized by jaundice, an enlarged liver, and profound brain damage. Children with this type rarely live beyond 18 months. Type B involves an enlarged liver and spleen, which usually occurs in the pre-teen years. The brain is not affected. Most patients present with <1% normal levels of the enzyme in comparison to normal levels.

An excess of spingomyelin in the red blood cell membrane (as in abetalipoproteinemia) causes excess lipid accumulation in the outer leaflet of the red blood cell plasma membrane. This results in abnormally shaped red cells called acanthocytes.
  Copyright: Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
 
 

BASIC PART PROPERTIES
  Type: COMPONENT
  Status: ACTIVE
  Created On: 5/4/2000

LANGUAGE VARIANTS
 
  Chinese (CHINA)  (From: Lin Zhang, A LOINC volunteer from China)   SYNONYMS
  神经鞘磷脂     神经磷脂;神经鞘骨磷脂;鞘磷脂
 
  Dutch (NETHERLANDS)  (From: NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)    
  sfingomyeline      
 
  Estonian (ESTONIA)  (From: Estonian E-Health Foundation)    
  Sfingomüeliin      
 
  French (BELGIUM)  (From: Jean M. Prevost, MD, Biopathology)    
  Sphingomyéline      
 
  French (CANADA)  (From: Canada Health Infoway Inc.)    
  Sphingomyéline      
 
  Italian (ITALY)  (From: Consiglio Nazionale delle Ricerche)    
  Sfingomielina      
 
  Russian (RUSSIAN FEDERATION)  (From: Yaroslavl State Medical Academy)    
  Сфингомиелин      
 
  Spanish (SPAIN)  (From: the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)    
  Esfingomielina      
 
  Turkish (TURKEY)  (From: LOINC Turkish Translation Group and the Turkish Ministry of Health)    
  Sfingomiyelin      

INTERNAL FIELDS
  Detail Page Created On: 6/20/2019 9:33:37 AM
  Display name: Sphingomyelin
  Preferred Abbreviation: Sphingomyelin