LP15315-2     Acetylcholinesterase

DESCRIPTION
  Part: Acetylcholinesterase
  Description: Acetylcholinesterase, an enyzme (EC 3.1.1.7) (AChE) that controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine, is also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase. The ACHE gene is mapped to chromosome 7q22. AChE is found primarily in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses. Two main clinical diagnostic uses are: 1) a second trimester screening test for fetal neural tube defects using amniotic fluid and, 2) in the general population, to detect past exposure to organophosphate insecticides with resultant inhibition of the enzyme using blood.
 
 
  Part: Acetylcholinesterase
  Description: In biochemistry, cholinesterase is a term which refers to one of the two enzymes:Acetylcholinesterase (EC 3.1.1.7) (AChE), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses Pseudocholinesterase (EC 3.1.1.8) (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver Both of these compounds catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. The difference between the two types of cholinesterase has to do with their respective preferences for substrates:the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.
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  Part: Acetylcholinesterase
  Description: An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
 
 

BASIC PART PROPERTIES
  Construct for LOINC short name: AChE
  Type: COMPONENT
  Status: ACTIVE
  Created On: 5/4/2000

LANGUAGE VARIANTS
 
  Chinese (CHINA)  (From: Lin Zhang, A LOINC volunteer from China)   SYNONYMS
  乙酰胆碱酯酶     AChE;真性胆碱酯酶;真胆碱酯酶;胆碱酯酶 I
 
  Dutch (NETHERLANDS)  (From: NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)    
  acetylcholinesterase      
 
  Estonian (ESTONIA)  (From: Estonian E-Health Foundation)    
  Atsetüülkoliini esteraas      
 
  French (BELGIUM)  (From: Jean M. Prevost, MD, Biopathology)    
  Acétylcholinestérase      
 
  French (CANADA)  (From: Canada Health Infoway Inc.)    
  Acétylcholinestérase      
 
  Italian (ITALY)  (From: Consiglio Nazionale delle Ricerche)    
  Acetilcolinesterasi      
 
  Russian (RUSSIAN FEDERATION)  (From: Yaroslavl State Medical Academy)    
  Ацетилхолинэстераза      
 
  Spanish (SPAIN)  (From: the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)   SYNONYMS
  Acetilcolinesterasa     Acetilcolinesterasa
 
  Turkish (TURKEY)  (From: LOINC Turkish Translation Group and the Turkish Ministry of Health)    
  Asetilkolinesteraz      

INTERNAL FIELDS
  Detail Page Created On: 6/20/2019 9:32:42 AM
  Display name: Acetylcholinesterase
  Preferred Abbreviation: AChE