LP14255-1     Cytomegalovirus

DESCRIPTION
  Part: Cytomegalovirus
  Description: Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html]
 
 

BASIC PART PROPERTIES
  Construct for LOINC short name: CMV
  Type: COMPONENT
  Status: ACTIVE
  Created On: 5/4/2000

LANGUAGE VARIANTS
 
  Chinese (CHINA)  (From: Lin Zhang, A LOINC volunteer from China)   SYNONYMS
  巨细胞病毒     CMV;涎腺病毒;细胞巨化病毒;细胞肥大病毒
 
  Dutch (NETHERLANDS)  (From: NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)    
  Cytomegalovirus      
 
  Estonian (ESTONIA)  (From: Estonian E-Health Foundation)    
  Tsütomegaloviirus      
 
  French (BELGIUM)  (From: Jean M. Prevost, MD, Biopathology)   SYNONYMS
  Cytomégalovirus     CMV
 
  French (CANADA)  (From: Canada Health Infoway Inc.)    
  Cytomégalovirus      
 
  Italian (ITALY)  (From: Consiglio Nazionale delle Ricerche)    
  Citomegalovirus      
 
  Russian (RUSSIAN FEDERATION)  (From: Yaroslavl State Medical Academy)    
  Цитомегаловирус      
 
  Spanish (SPAIN)  (From: the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)   SYNONYMS
  Citomegalovirus     CMV
 
  Turkish (TURKEY)  (From: LOINC Turkish Translation Group and the Turkish Ministry of Health)    
  Cytomegalovirus      

INTERNAL FIELDS
  Detail Page Created On: 6/20/2019 9:27:59 AM
  Display name: Cytomegalovirus
  Preferred Abbreviation: CMV