82729-5  Natural killer cell cytotoxicity.100:1 effector to target cell ratio/​Positive control in Blood mononuclear cellsNatural killer cell cytotoxicity.100:1 effector to target cell ratio/​Positive control in Blood mononuclear cellsNatural killer cell cytotoxicity.100:1 effector to target cell ratio/​Positive control: RelACnc: Pt: Bld MC: Qn:  

NAME
  Fully-Specified Name: 
Component   Property   Time   System   Scale   Method
Natural killer cell cytotoxicity.100:1 effector to target cell ratio/Positive control  RelACnc  Pt  Bld MC  Qn 
  Long Common Name:  Natural killer cell cytotoxicity.100:1 effector to target cell ratio/Positive control in Blood mononuclear cells
  Shortname:  NK cytotox.100:1 E:T/Pos cntrl Bld MC

PART DEFINITION/DESCRIPTION(S)
  Part: Natural killer cell cytotoxicity
  Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. [PMID: 14685277] In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. [PMID: 1842510] Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined using titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control. The result is reported as a percent.[http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/28562]
 
 

BASIC ATTRIBUTES
  Class/Type: HEM/BC/Lab
  First Released in Version: 2.58
  Last Updated in Version: 2.63
  Order vs. Obs.: Observation
  Status: Active

MEMBER OF THESE PANELS
  82720-4   Natural killer cell cytotoxicity panel - Blood mononuclear cellsNatural killer cell cytotoxicity panel - Blood mononuclear cellsNatural killer cell cytotoxicity panel: -: Pt: Bld MC: -:

PARTS

Part Type    Part No.  Part Name   
Component   LP230182-0  Natural killer cell cytotoxicity.100:1 effector to target cell ratio 
     Divisors   LP204182-2  Positive control 
Property   LP35077-4  RelACnc   [Relative Arbitrary Concentration] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP193850-7  Bld MC   [Blood mononuclear cells] 
Scale   LP7753-9  Qn 
Fragments for synonyms   LP21065-5  Positive 
Fragments for synonyms   LP21265-1 
Fragments for synonyms   LP264987-1  Natural killer cell cytotoxicity 
Fragments for synonyms   LP89546-3  Natural killer 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  自然杀伤细胞细胞毒性.100:1 效应细胞-靶细胞比值/​阳性对照:  相对任意型浓度:  时间点:  全血单个核细胞:  定量型:  自然杀伤细胞细胞毒性.100:1 效应细胞-靶细胞比值/​阳性对照:  相对任意型浓度:  时间点:  全血单个核细胞:  定量型:  自然杀伤细胞细胞毒性.100:1 效应细胞-靶细胞比值/​阳性对照:  相对任意型浓度:  时间点:  全血单个核细胞:  定量型:  
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Cytotoxicité cellules NK Patient 100/​1 %:  Activité arbitraire relative:  Ponctuel:  Cellules mononuclées de sang périphérique:  Numérique:  Cytotoxicité cellules NK Patient 100/​1 %:  Activité arbitraire relative:  Ponctuel:  Cellules mononuclées de sang périphérique:  Numérique:  Cytotoxicité cellules NK Patient 100/​1 %:  Activité arbitraire relative:  Ponctuel:  Cellules mononuclées de sang périphérique:  Numérique:  
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Cellula natural killer, citotossicità.rapporto 100:1 effettore verso cellula target/​Controllo positivo:  RelACnc:  Pt:  Cellule mononucleate da sangue intero:  Qn:  Cellula natural killer, citotossicità.rapporto 100:1 effettore verso cellula target/​Controllo positivo:  RelACnc:  Pt:  Cellule mononucleate da sangue intero:  Qn:  Cellula natural killer, citotossicità.rapporto 100:1 effettore verso cellula target/​Controllo positivo:  RelACnc:  Pt:  Cellule mononucleate da sangue intero:  Qn:  
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Citotoxicidad de las células Natural killer. Proporción efector con célula diana 100: 1/​Control positivo:  Concentración arbitraria relativa:  Punto temporal:  Celulas Mononucleares en sangre:  Qn:  Citotoxicidad de las células Natural killer. Proporción efector con célula diana 100: 1/​Control positivo:  Concentración arbitraria relativa:  Punto temporal:  Celulas Mononucleares en sangre:  Qn:  Citotoxicidad de las células Natural killer. Proporción efector con célula diana 100: 1/​Control positivo:  Concentración arbitraria relativa:  Punto temporal:  Celulas Mononucleares en sangre:  Qn:  

RELATED NAMES
  Blood Point in time Random
  HEMATOLOGY/CELL COUNTS Pos RlACnc
  i Pos cntrl WB
  NK QNT Whole blood
  NK cytotox.100:1 E:T Quan  
  PBMC Quant  
  Peripheral blood mononuclear cells Quantitative  

EXAMPLE UNITS
  Unit  Source Type
  EXAMPLE UCUM UNITS 

UNITS (INTERNAL DETAILS)
  Source Type:  EXAMPLE UCUM UNITS 
  Unit: 

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 12/13/2017 12:53:12 AM
  Long Common Name: Natural killer cell cytotoxicity.100:1 effector to target cell ratio/Positive control in Blood mononuclear cells
  Shortname: NK cytotox.100:1 E:T/Pos cntrl Bld MC
  Fully Specified Name: Natural killer cell cytotoxicity.100:1 effector to target cell ratio/Positive control: RelACnc: Pt: Bld MC: Qn:
     
  Component Word Count: 13
  ID: 87062
  Status (Raw): ACTIVE