76479-5  Acetylcholinesterase [Interpretation] in Amniotic fluid NarrativeAcetylcholinesterase [Interpretation] in Amniotic fluid NarrativeAcetylcholinesterase: Imp: Pt: Amnio fld: Nar:  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Acetylcholinesterase  Imp  Pt  Amnio fld  Nar 
  Long Common Name:  Acetylcholinesterase [Interpretation] in Amniotic fluid Narrative
  Short Name:  AChE Amn-Imp
  Display Name:  Acetylcholinesterase Nar (Amn fld) [Interp]

TERM DEFINITION/DESCRIPTION(S)
  An interpretation of the acetylcholinesterase (AChE) in amniotic fluid testing result which is used as an aid to diagnose open neural tube defect (NDT) and ventral wall defects. The two most common neural tube defects are spina bifida and anencephaly. When an NTD is suspected based upon maternal serum alpha-fetoprotein (AFP) screening results, or diagnosed via ultrasound, detection of acetylcholinesterase (AChE) in amniotic fluid is a useful diagnostic tool as normal amniotic fluid does not contain AChE, unless from the fetus as a result of an open NTD. The patient's gestational age must be at least 13 weeks (second trimester) for accurate AChE detection. Optimal gestational age is 14 to 18 weeks. If acetylcholinesterase is present genetic consultation and high-resolution ultrasound may be suggested.
 
 

PART DEFINITION/DESCRIPTION(S)
  Part: Acetylcholinesterase
  Acetylcholinesterase, an enyzme (EC 3.1.1.7) (AChE) that controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine, is also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase. The ACHE gene is mapped to chromosome 7q22. AChE is found primarily in the blood on red blood cell membranes, in neuromuscular junctions, and in neural synapses. Two main clinical diagnostic uses are: 1) a second trimester screening test for fetal neural tube defects using amniotic fluid and, 2) in the general population, to detect past exposure to organophosphate insecticides with resultant inhibition of the enzyme using blood.
 
 
  Part: Acetylcholinesterase
  An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
 
 

BASIC ATTRIBUTES
  Class/Type: CHEM/Lab
  First Released in Version: 2.52
  Last Updated in Version: 2.58
  Order vs. Obs.: Observation
  Status: Active

MEMBER OF THESE PANELS     
  This section provides information about panels that contain this LOINC code.
  LOINC   Long Common Name  
  76478-7 Acetylcholinesterase panel - Amniotic fluid
  

PARTS

Part Type    Part No.  Part Name   
Component   LP15315-2  Acetylcholinesterase 
Property   LP6819-9  Imp   [Impression/interpretation of study] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7000-5  Amnio fld   [Amniotic fluid] 
Scale   LP7749-7  Nar 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  乙酰胆碱酯酶:印象:时间点:羊水:叙述型:乙酰胆碱酯酶:印象:时间点:羊水:叙述型:
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  acetylcholinesterase:interpretatie:moment:vruchtwater:tekstueel:acetylcholinesterase:interpretatie:moment:vruchtwater:tekstueel:
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Acétylcholinestérase:Impression/​interprétation d'étude:Temps ponctuel:Liquide amniotique:Narratif:Acétylcholinestérase:Impression/​interprétation d'étude:Temps ponctuel:Liquide amniotique:Narratif:
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Acétylcholinestérase:Impression/​interprétation d'étude:Temps ponctuel:Liquide amniotique:Narratif:Acétylcholinestérase:Impression/​interprétation d'étude:Temps ponctuel:Liquide amniotique:Narratif:
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Acetylcholinesterase:Imp:Pt:Amnio fld:Nar:Acetylcholinesterase:Imp:Pt:Amnio fld:Nar:Acétylcholinestérase [Interprétation] Liquide amniotique ; Résultat textuel
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Acetilcolinesterasi:Imp:Pt:Liquido amniotico:Nar:Acetilcolinesterasi:Imp:Pt:Liquido amniotico:Nar:
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Ацетилхолинэстераза:Впчт:ТчкВрм:Амниотич ждк:Опис:Ацетилхолинэстераза:Впчт:ТчкВрм:Амниотич ждк:Опис:
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Acetilcolinesterasa:Impresión/​interpretación del estudio:Punto temporal:Fluido Ammiótico:Narrativo:Acetilcolinesterasa:Impresión/​interpretación del estudio:Punto temporal:Fluido Ammiótico:Narrativo:
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Asetilkolinesteraz:İzlnm:Zmlı:Amniyon sv:Öykü:Asetilkolinesteraz:İzlnm:Zmlı:Amniyon sv:Öykü:

RELATED NAMES
  Acetycholinesterase Amniotic flu Interp
  Acetylcholine acetylhydrolase Amniotic fluid Interpretation
  Acetylhydrolase Chemistry Narrative
  AChE Choline esterase I Point in time
  ACLE Cholinesterase true Random
  AF Erythrocyte cholinesterase RBC cholinesterase
  Amn Impression Report
  Amn fl Impression/interpretation of study  
  Amnio Impressions  

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 2:34:31 PM
  Long Common Name: Acetylcholinesterase [Interpretation] in Amniotic fluid Narrative
  Shortname: AChE Amn-Imp
  Fully Specified Name: Acetylcholinesterase: Imp: Pt: Amnio fld: Nar:
     
  Component Word Count: 1
  ID: 78736
  Status (Raw): ACTIVE