69002-4  Human papilloma virus E6+​E7 mRNA [Presence] in Cervix by NAA with probe detectionHuman papilloma virus E6+​E7 mRNA [Presence] in Cervix by NAA with probe detectionHuman papilloma virus 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA: PrThr: Pt: Cvx: Ord: Probe.amp.tar  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA  PrThr  Pt  Cvx  Ord  Probe.amp.tar
  Long Common Name:  Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection
  Short Name:  HPV E6+E7 mRNA Cvx Ql NAA+probe
  Display Name:  HPV E6+E7 mRNA NAA+probe Ql (Cvx)

TERM DEFINITION/DESCRIPTION(S)
  This term was created for (but not limited to) Gen-Probe's Aptima HPV assay (Cat No. 302610) that detects the E6 and E7 polycistronic mRNA from 14 high-risk HPV genotypes (16,18,31,33,35,39,45,51,52,56,58,59,66,and 68) that can lead to cervical cancer. E6/E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. This test is similar to LOINC 69358-0, which measures cells containing E6+E7 mRNA via flow cytometry.
 
 

PART DEFINITION/DESCRIPTION(S)
  Part: Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
  Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions.
 
 

BASIC ATTRIBUTES
  Class/Type: MICRO/Lab
  First Released in Version: 2.38
  Last Updated in Version: 2.63
  Order vs. Obs.: Both
  Status: Active.
Change Reason: The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.

EXAMPLE ANSWER LIST    (LL360-9)  
 
Source: Regenstrief Institute
  SEQ#        Answer        Answer ID    
  1       Positive
http://snomed.info/sct ©: 10828004 Positive (qualifier value)    
  LA6576-8  
  2       Negative
http://snomed.info/sct ©: 260385009 Negative (qualifier value)    
  LA6577-6  

EXAMPLE ANSWERS
  Positive
Negative

MEMBER OF THESE PANELS     
  This section provides information about panels that contain this LOINC code.
  LOINC   Long Common Name  
  72199-3 HEDIS 2013 panel
  74234-6 HEDIS 2014 Value Sets
  79544-3 HEDIS 2016 Value Sets
  82955-6 HEDIS 2017 Value Sets
  86636-8 Family planning report - FPAR 2.0 set
  87625-0 HEDIS 2018 Value Sets
  90766-7 HEDIS 2019 Value Sets
  

PARTS

Part Type    Part No.  Part Name   
Component   LP135722-9  Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA   [Human papilloma virus E6+E7 mRNA] 
Property   LP217195-9  PrThr   [Presence or Threshold] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7162-3  Cvx   [Cervix] 
Scale   LP7751-3  Ord 
Method   LP6464-4  Probe.amp.tar   [Nucleic acid amplification with probe detection] 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  人乳头瘤病毒 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 型 mRNA:存在情况或阈值:时间点:子宫颈:序数型:探针法.基因扩增.靶向人乳头瘤病毒 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 型 mRNA:存在情况或阈值:时间点:子宫颈:序数型:探针法.基因扩增.靶向
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  Humaan papillomavirus 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA:aanwezigheid:moment:cervix:ordinaal:moleculaire techniek (PCR)Humaan papillomavirus 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA:aanwezigheid:moment:cervix:ordinaal:moleculaire techniek (PCR)
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Human papilloma virus 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA:PrThr:Pt:Cvx:Ord:Probe.amp.tarHuman papilloma virus 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA:PrThr:Pt:Cvx:Ord:Probe.amp.tarPapillomavirus humain 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 ARNm [Présence/​Seuil] Col de l'utérus ; Qualitatif ; PCR amplification de cible
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Papilloma virus umano 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA:PrThr:Pt:Cvx:Ord:Sonda.amp.tarPapilloma virus umano 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA:PrThr:Pt:Cvx:Ord:Sonda.amp.tar
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Вирус папилломы человека 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 мРНК:PrThr:ТчкВрм:Шейка:Пор:Проба.усил.мишВирус папилломы человека 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 мРНК:PrThr:ТчкВрм:Шейка:Пор:Проба.усил.миш
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  ARN m de Papilomavirus humano 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7:PrThr:Punto temporal:Cuello uterino:Ord:Sonda con amplificación dirigidaARN m de Papilomavirus humano 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7:PrThr:Punto temporal:Cuello uterino:Ord:Sonda con amplificación dirigida
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Human papilloma virüsü 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA:MevcEşik:Zmlı:Cvx:Srl:Prob.amf.hdfHuman papilloma virüsü 16+​18+​31+​33+​35+​39+​45+​51+​52+​56+​58+​59+​66+​68 E6+​E7 mRNA:MevcEşik:Zmlı:Cvx:Srl:Prob.amf.hdf

RELATED NAMES
  3 Self-Sustaining Sequence Replication HPV16+18 Polymerase chain reaction
  3SR SR HPV16+18+H Risk 12 PR
  Amplif Human papillomavirus Probe amp
  Amplification LAT Probe with ampification
  Amplified LCR Probe with target amplification
  Cervix Ligase chain reaction QBR
  DNA NUCLEIC ACID PROBE Ligation-activated transcription QL
  DNA probe Microbiology Qual
  Genital tract NAA+probe Qualitative
  Genital warts NAAT Random
  HPV NASBA Screen
  HPV E6+E7 Nucleic acid sequence based analysis SDA
  HPV E6+E7 mRNA Ordinal Strand Displacement Amplification
  HPV I/H Risk 4 Papilloma virus high risk TMA
  HPV16 PCR Transcription mediated amplification
  HPV16 and 18 Point in time  

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 3:30:56 PM
  Attachment Units Required: N
  Long Common Name: Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection
  Shortname: HPV E6+E7 mRNA Cvx Ql NAA+probe
  Fully Specified Name: Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA: PrThr: Pt: Cvx: Ord: Probe.amp.tar
     
  Component Word Count: 20
  ID: 68313
  Status (Raw): ACTIVE

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