Version 2.77

Term Description

This term was created for (but not limited to) Gen-Probe's Aptima HPV assay (Cat No. 302610) that detects the E6 and E7 polycistronic mRNA from 14 high-risk HPV genotypes (16,18,31,33,35,39,45,51,52,56,58,59,66,and 68) that can lead to cervical cancer. E6/E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. This test is similar to LOINC 69358-0, which measures cells containing E6+E7 mRNA via flow cytometry.
Source: Regenstrief LOINC

Part Description

LP135722-9   Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Most human papilloma virus (HPV) genomes encode for eight major proteins, six "early" (E1, E2, E3, E4, E6, and E7) and two "late" (L1 and L2). The "early" are regulatory in function. E6 and E7 genes in high-risk HPV genotypes are known as oncogenes because of their continuous expression, which leads to disruption of cell-cycle check points and cell genome instability through alteration of cellular p53 and retinoblastoma protein functions. Source: Regenstrief LOINC

Fully-Specified Name

Component
Human papilloma virus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA
Property
PrThr
Time
Pt
System
Cvx
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
HPV E6+E7 mRNA Cvx Ql NAA+probe
Display Name
HPV E6+E7 mRNA NAA+probe Ql (Cvx)
Consumer Name Alpha Get Info
HPV E6+E7 MRNA, Cervix

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.38
Last Updated
Version 2.73
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both
Common Test Rank Get Info
1194

Member of these Panels

LOINC Long Common Name
86636-8 Family planning report - FPAR 2.0 set
72199-3 HEDIS 2013 panel
74234-6 HEDIS 2014 Value Sets
79544-3 HEDIS 2016 Value Sets
82955-6 HEDIS 2017 Value Sets
87625-0 HEDIS 2018 Value Sets
90766-7 HEDIS 2019 Value Sets
94137-7 HEDIS 2020 Value Sets
96068-2 HEDIS MY 2020 Value Sets

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) ARN m de Papilomavirus humano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7:PrThr:Punto temporal:Cuello uterino:Ord:Sonda con amplificación dirigida
es-MX Spanish (Mexico) Virus del papiloma humano 16 + 18 + 31 + 33 + 35 + 39 + 45 + 51 + 52 + 56 + 58 + 59 + 66 + 68 ARNm de E6 + E7:Presencia o umbral:Punto temporal:Cuello uterino:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Papillomavirus humain 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 ARNm:Présence/Seuil:Ponctuel:Col de l'utérus:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Papilloma virus umano 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:PrThr:Pt:Cvx:Ord:Sonda.amp.tar
Synonyms: Cervice uterina HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 Microbiologia mRNA di E6+E7 papilloma virus umano Papilloma virus umano 16 e 18 Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA
nl-NL Dutch (Netherlands) Humaan papillomavirus 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:aanwezigheid:moment:cervix:ordinaal:probe-detectie
Synonyms: baarmoederhals probe.amp.tar
ru-RU Russian (Russian Federation) Вирус папилломы человека 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 мРНК:PrThr:ТчкВрм:Шейка:Пор:Проба.усил.миш
Synonyms: ДНК проба;ДНК зонд Порядковый Проба с мишени усилением Точка во времени;Момент
tr-TR Turkish (Turkey) Human papilloma virüsü 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 mRNA:MevcEşik:Zmlı:Cvx:Srl:Prob.amf.hdf
Synonyms: Mevcut
zh-CN Chinese (China) 人乳头瘤病毒 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA:存在情况或阈值:时间点:子宫颈:序数型:探针法.基因扩增.靶向
Synonyms: HPV 16 & 18 & 31+33+35+39+45+51+52+56+58+59+66+68 HPV 16 & 18;HPV 16 & 18 型;HPV16 & 18;人类乳头瘤病毒 16 & 18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16;HPV 16 型;HPV16;人类乳头瘤病毒 16 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16+18;HPV 16+18 型;HPV16+18;人类乳头瘤病毒 16+18 型;高危 HPV;高危型 HPV;高危型人乳头瘤病毒;高危型人类乳头瘤病毒 HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 E6+E7 型 mRNA HPV 16+18+31+33+35+39+45+51+52+56+58+59+66+68 型 HPV;人乳头瘤病毒(Human papilloma virus,HPV);人类乳头瘤病毒;生殖器疣 传染毒;传染毒素;滤过性病原体;病毒类;过滤性病原体 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 宫颈;生殖道 微生物学;微生物学试验;微生物学试验(培养、DNA、抗原及抗体) 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针

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