62388-4  Hemoglobin A1c/​Hemoglobin.total in Blood by JDS/​JSCC protocolHemoglobin A1c/​Hemoglobin.total in Blood by JDS/​JSCC protocolHemoglobin A1c/​Hemoglobin.total: MFr: Pt: Bld: Qn: JDS/​JSCC  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Hemoglobin A1c/Hemoglobin.total  MFr  Pt  Bld  Qn  JDS/JSCC
  Long Common Name:  Hemoglobin A1c/Hemoglobin.total in Blood by JDS/JSCC protocol
  Short Name:  Hgb A1c MFr Bld JDS/JSCC
  Display Name:  HbA1c JDS/JSCC protocol (Bld) [Mass fraction]

TERM DEFINITION/DESCRIPTION(S)
  Japan is the main country that uses this protocol, but not exclusively.
 
 

PART DEFINITION/DESCRIPTION(S)
  Part: Hemoglobin A1c
  Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as “HPLC”, “electrophoresis” or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol – no decimals) and NGSP derived units (percentage – one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent – i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.
 
 

BASIC ATTRIBUTES
  Class/Type: HEM/BC/Lab
  First Released in Version: 2.34
  Last Updated in Version: 2.40
  Order vs. Obs.: Both
  Status: Active

MEMBER OF THESE PANELS     
  This section provides information about panels that contain this LOINC code.
  LOINC   Long Common Name  
  74234-6 HEDIS 2014 Value Sets
  

PARTS

Part Type    Part No.  Part Name   
Component   LP16413-4  Hemoglobin A1c 
     Divisors   LP32069-4  Hemoglobin.total 
Property   LP6831-4  MFr   [Mass fraction] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7057-5  Bld   [Blood] 
Scale   LP7753-9  Qn 
Method   LP111462-0  JDS/JSCC   [JDS/JSCC protocol] 
Fragments for synonyms   LP21089-5  Total 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  血红蛋白 A1c/​血红蛋白.总计:质量分数:时间点:全血:定量型:JDS/​JSCC血红蛋白 A1c/​血红蛋白.总计:质量分数:时间点:全血:定量型:JDS/​JSCC
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  hemoglobine A1c/​hemoglobine.totaal:massafractie:moment:bloed:kwantitatief:JDS/​JSCChemoglobine A1c/​hemoglobine.totaal:massafractie:moment:bloed:kwantitatief:JDS/​JSCC
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Hemoglobin A1c/​Hemoglobin.total:MFr:Pt:Bld:Qn:JDS/​JSCCHemoglobin A1c/​Hemoglobin.total:MFr:Pt:Bld:Qn:JDS/​JSCCHémoglobine A1c/​hémoglobine totale [Fraction massique] Sang ; Numérique ; JDS/​JSCC
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Emoglobina A1c/​Emoglobina.totale:MFr:Pt:Sangue:Qn:JDS/​JSCCEmoglobina A1c/​Emoglobina.totale:MFr:Pt:Sangue:Qn:JDS/​JSCC
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Hemoglobina A1c (Hemoglobina glicosilada)/​Hemoglobina.total:Fracción de masa:Punto temporal:Sangre:Qn:JDS/​JSCCHemoglobina A1c (Hemoglobina glicosilada)/​Hemoglobina.total:Fracción de masa:Punto temporal:Sangre:Qn:JDS/​JSCC
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Hemoglobin A1c/​Hemoglobin.total:KütlFr:Zmlı:Kan:Kant:JDS/​JSCCHemoglobin A1c/​Hemoglobin.total:KütlFr:Zmlı:Kan:Kant:JDS/​JSCC

RELATED NAMES
  Blood HbA1c Quan
  GHb HEMATOLOGY/CELL COUNTS Quant
  Glycated hemoglobin Hgb Quantitative
  Glycohaemogolobin Hgb A1c Random
  Glycohemogolobin Japanese Diabetes Society/Japanese Society for Clinical Chemistry Tot
  Glycosylated hemoglobin Mass fraction Totl
  HA1c Percent WB
  Haemoglobin Point in time Whole blood
  Hb QNT  

EXAMPLE UNITS
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  EXAMPLE UCUM UNITS 

UNITS (INTERNAL DETAILS)
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  Unit: 

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 4:10:13 PM
  Attachment Units Required: N
  Long Common Name: Hemoglobin A1c/Hemoglobin.total in Blood by JDS/JSCC protocol
  Shortname: Hgb A1c MFr Bld JDS/JSCC
  Fully Specified Name: Hemoglobin A1c/Hemoglobin.total: MFr: Pt: Bld: Qn: JDS/JSCC
     
  Component Word Count: 4
  ID: 57561
  Status (Raw): ACTIVE