57775-9  Valproate.free and Valproate panel - Serum or PlasmaValproate.free and Valproate panel - Serum or PlasmaValproate.free & Valproate panel: -: Pt: Ser/​Plas: Qn:  

PANEL HIERARCHY  (view this panel in the LForms viewer)

  LOINC#   LOINC Name R/O/C  Cardinality  Ex. UCUM Units 
  57775-9   Valproate.free and Valproate panel - Serum or PlasmaValproate.free and Valproate panel - Serum or PlasmaValproate.free & Valproate panel: -: Pt: Ser/​Plas: Qn:    
       4087-3   Valproate Free [Mass/​volume] in Serum or PlasmaValproate Free [Mass/​volume] in Serum or PlasmaValproate.free: MCnc: Pt: Ser/​Plas: Qn: R   ug/mL 
       4086-5   Valproate [Mass/​volume] in Serum or PlasmaValproate [Mass/​volume] in Serum or PlasmaValproate: MCnc: Pt: Ser/​Plas: Qn: R   ug/mL 
 

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Valproate.free & Valproate panel  Pt  Ser/Plas  Qn 
  Long Common Name:  Valproate.free and Valproate panel - Serum or Plasma
  Short Name:  Valproate.free + Valproate pnl SerPl
  Display Name:  Valproate.free and Valproate panel

PART DEFINITION/DESCRIPTION(S)
  Part: free DRUG/TOX
  The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug [PMID: 6636249] . For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity.
 
 

BASIC ATTRIBUTES
  Class/Type: PANEL.DRUG/TOX/Lab
  Panel Type: Panel
  First Released in Version: 2.29
  Last Updated in Version: 2.42
  Order vs. Obs.: Order
  Status: Active

PARTS

Part Type    Part No.  Part Name   
Component   LP97609-9  Valproate.free & Valproate panel   [Valproate.free and Valproate panel] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7576-4  Ser/Plas   [Serum or Plasma] 
Scale   LP7753-9  Qn 
Fragments for synonyms   LP20769-3  Free 
Fragments for synonyms   LP21059-8  Panel 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  2-丙基戊酸.游离型与2-丙基戊酸.游离型组套:-:时间点:血清/​血浆:定量型:2-丙基戊酸.游离型与2-丙基戊酸.游离型组套:-:时间点:血清/​血浆:定量型:
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  valproaat.vrij & valproaat panel:-:moment:serum of plasma:kwantitatief:valproaat.vrij & valproaat panel:-:moment:serum of plasma:kwantitatief:
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Valproate.libre & Valproate:-:Temps ponctuel:Sérum/​Plasma:Quantitatif:Valproate.libre & Valproate:-:Temps ponctuel:Sérum/​Plasma:Quantitatif:
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Valproate.libre & Valproate:-:Temps ponctuel:Sérum/​Plasma:Quantitatif:Valproate.libre & Valproate:-:Temps ponctuel:Sérum/​Plasma:Quantitatif:
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Valproate.free & Valproate panel:-:Pt:Ser/​Plas:Qn:Valproate.free & Valproate panel:-:Pt:Ser/​Plas:Qn:Valproate libre et valproate panel [-] Sérum/​Plasma ; Numérique
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Valproato.libero & Valproato, panel:-:Pt:Siero/​Plasma:Qn:Valproato.libero & Valproato, panel:-:Pt:Siero/​Plasma:Qn:
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  Valproato.livre e Valproato painel:#N/​A:Pt:Sor/​Plas:Qn:Valproato.livre e Valproato painel:#N/​A:Pt:Sor/​Plas:Qn:
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Вальпроат.свободный & Вальпроат панель:-:ТчкВрм:Сыв/​Плаз:Колич:Вальпроат.свободный & Вальпроат панель:-:ТчкВрм:Сыв/​Плаз:Колич:
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Panel de valproico y valproico libre:Propiedades mixtas (sólo paneles):Punto temporal:Suero o Plasma:Qn:Panel de valproico y valproico libre:Propiedades mixtas (sólo paneles):Punto temporal:Suero o Plasma:Qn:
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Valproat.serb ve Valproat paneli:-:Zmlı:Ser/​Plaz:Kant:Valproat.serb ve Valproat paneli:-:Zmlı:Ser/​Plaz:Kant:

RELATED NAMES
  Depakene Plasma SerPl
  Divalproex Plsm SerPlas
  DRUG/TOXICOLOGY Pnl Serum
  Drugs Point in time Serum or plasma
  FR QNT SR
  Non-protein bound Quan VALP
  Pan Quant Valproate Free
  PANEL.DRUG & TOXICOLOGY Quantitative Valproate.free + Valproate pnl
  Panl Random Valproic acid
  Pl SerP  

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 4:33:00 PM
  Attachment Units Required: N
  Long Common Name: Valproate.free and Valproate panel - Serum or Plasma
  Shortname: Valproate.free + Valproate pnl SerPl
  Fully Specified Name: Valproate.free & Valproate panel: -: Pt: Ser/Plas: Qn:
     
  Component Word Count: 4
  ID: 52446
  # of Panel Elements: 3
  Status (Raw): ACTIVE



Selected information about each LOINC that is part of this panel



4087-3   Valproate Free [Mass/​volume] in Serum or PlasmaValproate Free [Mass/​volume] in Serum or PlasmaValproate.free: MCnc: Pt: Ser/​Plas: Qn:  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Valproate.free  MCnc  Pt  Ser/Plas  Qn 
  Long Common Name:  Valproate Free [Mass/volume] in Serum or Plasma
  Short Name:  Valproate Free SerPl-mCnc
  Display Name:  Valproate Free [Mass/Vol]

PART DEFINITION/DESCRIPTION(S)
  Part: free DRUG/TOX
  The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug [PMID: 6636249] . For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity.
 
 

OBSERVATION REQUIRED IN PANEL
Required

BASIC ATTRIBUTES
  Class/Type: DRUG/TOX/Lab
  First Released in Version: 1.0
  Last Updated in Version: 2.63
  Mass or Substance Property: M
  Order vs. Obs.: Both
  Status: Active.
Change Reason: Order_Obs: changed from 'observation' to 'both' to reflect that the LOINC code can also be used as an order code.

MEMBER OF THESE PANELS     
  This section provides information about panels that contain this LOINC code.
  LOINC   Long Common Name  
  54037-7 HEDIS 2009 panel
  57775-9 Valproate.free and Valproate panel - Serum or Plasma
  57820-3 HEDIS 2010 panel
  60442-1 HEDIS 2011 panel
  67767-4 HEDIS 2012 panel
  72199-3 HEDIS 2013 panel
  74234-6 HEDIS 2014 Value Sets
  

MEMBER OF THESE EQUIVALENCE GROUPS
  LG47174-4  Valproate.free|Pt|Ser/Plas

PARTS

Part Type    Part No.  Part Name   
Component   LP29130-9  Valproate.free   [Valproate Free] 
Property   LP6827-2  MCnc   [Mass Concentration] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7576-4  Ser/Plas   [Serum or Plasma] 
Scale   LP7753-9  Qn 
Fragments for synonyms   LP20769-3  Free 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  2-丙基戊酸.游离型:质量浓度:时间点:血清/​血浆:定量型:2-丙基戊酸.游离型:质量浓度:时间点:血清/​血浆:定量型:
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  valproaat.vrije:massa/​volume:moment:serum of plasma:kwantitatief:valproaat.vrije:massa/​volume:moment:serum of plasma:kwantitatief:
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  Valproaat.vaba:MCnc:Pt:S/​P:Qn:Valproaat.vaba:MCnc:Pt:S/​P:Qn:
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Valproate.libre:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:Valproate.libre:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Valproate.libre:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:Valproate.libre:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Valproate.free:MCnc:Pt:Ser/​Plas:Qn:Valproate.free:MCnc:Pt:Ser/​Plas:Qn:Valproate libre [Masse/​Volume] Sérum/​Plasma ; Numérique
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Valproato.libero:MCnc:Pt:Siero/​Plasma:Qn:Valproato.libero:MCnc:Pt:Siero/​Plasma:Qn:
  Korean (KOREA, REPUBLIC OF)  (From: Korean Ministry for Health, Welfare, and Family Affairs)
 
  유리벨프로에이트:질량농도:검사시점:혈청/​혈장:정량:유리벨프로에이트:질량농도:검사시점:혈청/​혈장:정량:
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  Valproato.livre:MCnc:Pt:Sor/​Plas:Qn:Valproato.livre:MCnc:Pt:Sor/​Plas:Qn:
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Вальпроат.свободный:МассКонц:ТчкВрм:Сыв/​Плаз:Колич:Вальпроат.свободный:МассКонц:ТчкВрм:Сыв/​Плаз:Колич:
  Spanish (ARGENTINA)  (From: Conceptum Medical Terminology Center)
 
  valproato.libre:concentración de masa:punto en el tiempo:suero/​plasma:cuantitativo:valproato.libre:concentración de masa:punto en el tiempo:suero/​plasma:cuantitativo:
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Valproico libre:Concentración de masa:Punto temporal:Suero o Plasma:Qn:Valproico libre:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Valproat.serb:KütlKons:Zmlı:Ser/​Plaz:Kant:Valproat.serb:KütlKons:Zmlı:Ser/​Plaz:Kant:

RELATED NAMES
  Depakene Plasma SerPl
  Divalproex Plsm SerPlas
  DRUG/TOXICOLOGY Point in time Serum
  Drugs QNT Serum or plasma
  FR Quan SR
  Level Quant VALP
  Mass concentration Quantitative Valproate Free
  Non-protein bound Random Valproic acid
  Pl SerP  

EXAMPLE UNITS
  Unit  Source Type
  mcg/mL  REGENSTRIEF 
  ug/mL  EXAMPLE UCUM UNITS 

UNITS (INTERNAL DETAILS)
  Source Type:  REGENSTRIEF 
  Unit:  mcg/mL 
  Source Type:  EXAMPLE UCUM UNITS 
  Unit:  ug/mL 

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 4:33:00 PM
  Attachment Units Required: Y
  Long Common Name: Valproate Free [Mass/volume] in Serum or Plasma
  Shortname: Valproate Free SerPl-mCnc
  Fully Specified Name: Valproate.free: MCnc: Pt: Ser/Plas: Qn:
     
  Component Word Count: 2
  ID: 33817
  Status (Raw): ACTIVE


4086-5   Valproate [Mass/​volume] in Serum or PlasmaValproate [Mass/​volume] in Serum or PlasmaValproate: MCnc: Pt: Ser/​Plas: Qn:  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Valproate  MCnc  Pt  Ser/Plas  Qn 
  Long Common Name:  Valproate [Mass/volume] in Serum or Plasma
  Short Name:  Valproate SerPl-mCnc
  Display Name:  Valproate [Mass/Vol]

PART DEFINITION/DESCRIPTION(S)
  Part: Valproate
  Valproic acid is a compound used as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, juvenile myoclonic epilepsy and the seizures associated with Lennox-Gastaut syndrome. It is also used in treatment of myoclonus. In some countries, parenteral (administered intravenously) preparations of valproate are used also as second-line treatment of status epilepticus, alternatively to phenytoin. Related drugs include sodium valproate, used as an anticonvulsant, and a combined formulation, valproate semi-sodium, used as a mood stabilizer and anticonvulsant.
  Copyright: Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
 
 
  Part: Valproate
  Valproic acid is an anticonvulsant that is used alone or with other medication to treat certain types of seizures, mania in people with bipolar disorder, and to prevent migranes before they occur. it cannot be used to treat migranes once they begin.
Valproic acid can also be used for children with attention deficit hyperactivity disorder to treat outbursts of aggression or impaired intellectual functioning, developmental delays, and behavioral disturbances associated with Lennoz-Gastaut syndrome. [MedlinePlus Drug:a682412] [NINDS:/disorders/lennoxgastautsyndrome/lennoxgastautsyndrome]
 
 

OBSERVATION REQUIRED IN PANEL
Required

BASIC ATTRIBUTES
  Class/Type: DRUG/TOX/Lab
  Common Lab Results Rank: #408
  Common Orders Rank: #174
  First Released in Version: 1.0
  Last Updated in Version: 2.66
  Mass or Substance Property: M
  Order vs. Obs.: Both
  Status: Active

MEMBER OF THESE PANELS     
  This section provides information about panels that contain this LOINC code.
  LOINC   Long Common Name  
  54037-7 HEDIS 2009 panel
  55427-9 Seizure disorder tracking panel
  57775-9 Valproate.free and Valproate panel - Serum or Plasma
  57820-3 HEDIS 2010 panel
  60442-1 HEDIS 2011 panel
  67767-4 HEDIS 2012 panel
  72199-3 HEDIS 2013 panel
  74234-6 HEDIS 2014 Value Sets
  

MEMBER OF THESE EQUIVALENCE GROUPS
  LG49789-7  Valproate|Pt|Ser/Plas

PARTS

Part Type    Part No.  Part Name   
Component   LP16305-2  Valproate 
Property   LP6827-2  MCnc   [Mass Concentration] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7576-4  Ser/Plas   [Serum or Plasma] 
Scale   LP7753-9  Qn 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  2-丙基戊酸:质量浓度:时间点:血清/​血浆:定量型:2-丙基戊酸:质量浓度:时间点:血清/​血浆:定量型:
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  valproaat:massa/​volume:moment:serum of plasma:kwantitatief:valproaat:massa/​volume:moment:serum of plasma:kwantitatief:
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  Valproaat:MCnc:Pt:S/​P:Qn:Valproaat:MCnc:Pt:S/​P:Qn:
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Valproate:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:Valproate:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Valproate:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:Valproate:Concentration de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Valproate:MCnc:Pt:Ser/​Plas:Qn:Valproate:MCnc:Pt:Ser/​Plas:Qn:Valproate [Masse/​Volume] Sérum/​Plasma ; Numérique
  German (AUSTRIA)  (From: ELGA, Austria)
 
  Valproinsäure
  German (GERMANY)  (From: Institute for Medical Documentation and Information (DIMDI))
 
  Valproat:MKnz:Pkt:Ser/​Plas:Qn:Valproat:MKnz:Pkt:Ser/​Plas:Qn:
  Greek (GREECE)  (From: Regenstrief-generated full translation based on part translation provided by Efstratia Kontaxi, MD, MSc, and Evripidis Stefanidis, MD, with technical support from Panagiotis Kontaxis, Diploma of Electrical and Computer Engineering.)
 
  Βαλπροϊκό:Συγκέντρωση μάζας:Χρονική στιγμή:Ορός/​Πλάσμα:Ποσοτική:Βαλπροϊκό:Συγκέντρωση μάζας:Χρονική στιγμή:Ορός/​Πλάσμα:Ποσοτική:
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Valproato:MCnc:Pt:Siero/​Plasma:Qn:Valproato:MCnc:Pt:Siero/​Plasma:Qn:
  Korean (KOREA, REPUBLIC OF)  (From: Korean Ministry for Health, Welfare, and Family Affairs)
 
  벨프로에이트:질량농도:검사시점:혈청/​혈장:정량:벨프로에이트:질량농도:검사시점:혈청/​혈장:정량:
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  Valproato:MCnc:Pt:Sor/​Plas:Qn:Valproato:MCnc:Pt:Sor/​Plas:Qn:
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Вальпроат:МассКонц:ТчкВрм:Сыв/​Плаз:Колич:Вальпроат:МассКонц:ТчкВрм:Сыв/​Плаз:Колич:
  Spanish (ARGENTINA)  (From: Conceptum Medical Terminology Center)
 
  valproato:concentración de masa:punto en el tiempo:suero/​plasma:cuantitativo:valproato:concentración de masa:punto en el tiempo:suero/​plasma:cuantitativo:
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Valproato:Concentración de masa:Punto temporal:Suero o Plasma:Qn:Valproato:Concentración de masa:Punto temporal:Suero o Plasma:Qn:
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Valproat:KütlKons:Zmlı:Ser/​Plaz:Kant:Valproat:KütlKons:Zmlı:Ser/​Plaz:Kant:

RELATED NAMES
  Depakene Plsm SerPl
  Divalproex Point in time SerPlas
  DRUG/TOXICOLOGY QNT Serum
  Drugs Quan Serum or plasma
  Level Quant SR
  Mass concentration Quantitative VALP
  Pl Random Valproic acid
  Plasma SerP  

EXAMPLE UNITS
  Unit  Source Type
  mcg/mL  REGENSTRIEF 
  ug/mL  EXAMPLE UCUM UNITS 

UNITS (INTERNAL DETAILS)
  Source Type:  REGENSTRIEF 
  Unit:  mcg/mL 
  Source Type:  EXAMPLE UCUM UNITS 
  Unit:  ug/mL 

UNITS AND RANGE
  Range  Units Type
  ug/mL:[50,100]   

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 4:33:00 PM
  Attachment Units Required: Y
  Long Common Name: Valproate [Mass/volume] in Serum or Plasma
  Shortname: Valproate SerPl-mCnc
  Fully Specified Name: Valproate: MCnc: Pt: Ser/Plas: Qn:
     
  Component Word Count: 1
  ID: 33808
  Status (Raw): ACTIVE