32283-4  Valproate Free/​Valproate.total in Serum or PlasmaValproate Free/​Valproate.total in Serum or PlasmaValproate.free/​Valproate.total: MFr: Pt: Ser/​Plas: Qn:  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Valproate.free/Valproate.total  MFr  Pt  Ser/Plas  Qn 
  Long Common Name:  Valproate Free/Valproate.total in Serum or Plasma
  Short Name:  Valproate Free MFr SerPl
  Display Name:  Valproate Free/Valproate.total [Mass fraction]

PART DEFINITION/DESCRIPTION(S)
  Part: free DRUG/TOX
  The measurement of free (unbound) drug concentrations in plasma is important for certain drugs and has two advantages over measurement of total concentration: (1) the free concentration is independent of changes in plasma binding (e.g., due to changes in albumin), and (2) the free concentration is more directly related to both the efficacy and toxicity of the drug [PMID: 6636249] . For most drugs and the majority of patients, measuring the free and total concentrations is not necessary. However, for certain drugs, including some anticonvulsants and antibiotics, and specific patient populations, such as critically ill or immunosuppressed patients, the free concentration is a better indicator of therapeutic effect and potential toxicity.
 
 

BASIC ATTRIBUTES
  Class/Type: DRUG/TOX/Lab
  First Released in Version: 2.07
  Last Updated in Version: 2.30
  Order vs. Obs.: Observation
  Status: Active

MEMBER OF THESE PANELS     
  This section provides information about panels that contain this LOINC code.
  LOINC   Long Common Name  
  54037-7 HEDIS 2009 panel
  57820-3 HEDIS 2010 panel
  60442-1 HEDIS 2011 panel
  67767-4 HEDIS 2012 panel
  72199-3 HEDIS 2013 panel
  74234-6 HEDIS 2014 Value Sets
  

PARTS

Part Type    Part No.  Part Name   
Component   LP29130-9  Valproate.free   [Valproate Free] 
     Divisors   LP32177-5  Valproate.total 
Property   LP6831-4  MFr   [Mass fraction] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7576-4  Ser/Plas   [Serum or Plasma] 
Scale   LP7753-9  Qn 
Fragments for synonyms   LP20769-3  Free 
Fragments for synonyms   LP21089-5  Total 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  2-丙基戊酸.游离型/​2-丙基戊酸.总计:质量分数:时间点:血清/​血浆:定量型:2-丙基戊酸.游离型/​2-丙基戊酸.总计:质量分数:时间点:血清/​血浆:定量型:
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  valproaat.vrije/​valproaat.totaal:massafractie:moment:serum of plasma:kwantitatief:valproaat.vrije/​valproaat.totaal:massafractie:moment:serum of plasma:kwantitatief:
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  Valproaat.vaba/​valproaat.üld:MFr:Pt:S/​P:Qn:Valproaat.vaba/​valproaat.üld:MFr:Pt:S/​P:Qn:
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Valproate.libre/​Valproate.totale:Fraction de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:Valproate.libre/​Valproate.totale:Fraction de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Valproate.libre/​Valproate.totale:Fraction de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:Valproate.libre/​Valproate.totale:Fraction de masse:Temps ponctuel:Sérum/​Plasma:Quantitatif:
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Valproate.free/​Valproate.total:MFr:Pt:Ser/​Plas:Qn:Valproate.free/​Valproate.total:MFr:Pt:Ser/​Plas:Qn:Valproate libre/​valproate total [Fraction massique] Sérum/​Plasma ; Numérique
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Valproato.libero/​Valproato.totale:MFr:Pt:Siero/​Plasma:Qn:Valproato.libero/​Valproato.totale:MFr:Pt:Siero/​Plasma:Qn:
  Korean (KOREA, REPUBLIC OF)  (From: Korean Ministry for Health, Welfare, and Family Affairs)
 
  유리벨프로에이트/​총벨프로에이트:질량분획:검사시점:혈청/​혈장:정량:유리벨프로에이트/​총벨프로에이트:질량분획:검사시점:혈청/​혈장:정량:
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  Valproato.livre/​Valproato.total:MFr:Pt:Sor/​Plas:Qn:Valproato.livre/​Valproato.total:MFr:Pt:Sor/​Plas:Qn:
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Вальпроат.свободный/​Вальпроат.общий:МассДол:ТчкВрм:Сыв/​Плаз:Колич:Вальпроат.свободный/​Вальпроат.общий:МассДол:ТчкВрм:Сыв/​Плаз:Колич:
  Spanish (ARGENTINA)  (From: Conceptum Medical Terminology Center)
 
  valproato.libre/​valproato.total:fracción de masa:punto en el tiempo:suero/​plasma:cuantitativo:valproato.libre/​valproato.total:fracción de masa:punto en el tiempo:suero/​plasma:cuantitativo:
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Valproico libre/​Valproato total:Fracción de masa:Punto temporal:Suero o Plasma:Qn:Valproico libre/​Valproato total:Fracción de masa:Punto temporal:Suero o Plasma:Qn:
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Valproat.serb/​Valproat.total:KütlFr:Zmlı:Ser/​Plaz:Kant:Valproat.serb/​Valproat.total:KütlFr:Zmlı:Ser/​Plaz:Kant:

RELATED NAMES
  Depakene Plsm Serum
  Divalproex Point in time Serum or plasma
  DRUG/TOXICOLOGY QNT SR
  Drugs Quan Tot
  FR Quant Totl
  Mass fraction Quantitative VALP
  Non-protein bound Random Valproate Free
  Percent SerP Valproic acid
  Pl SerPl  
  Plasma SerPlas  

EXAMPLE UNITS
  Unit  Source Type
  EXAMPLE UCUM UNITS 
  REGENSTRIEF 

UNITS (INTERNAL DETAILS)
  Source Type:  EXAMPLE UCUM UNITS 
  Unit: 
  Source Type:  REGENSTRIEF 
  Unit: 

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 6:31:59 PM
  Attachment Units Required: N
  Long Common Name: Valproate Free/Valproate.total in Serum or Plasma
  Shortname: Valproate Free MFr SerPl
  Fully Specified Name: Valproate.free/Valproate.total: MFr: Pt: Ser/Plas: Qn:
     
  Component Word Count: 4
  ID: 24372
  Status (Raw): ACTIVE