17856-6  Hemoglobin A1c/​Hemoglobin.total in Blood by HPLCHemoglobin A1c/​Hemoglobin.total in Blood by HPLCHemoglobin A1c/​Hemoglobin.total: MFr: Pt: Bld: Qn: HPLC  

NAME
  Fully Specified Name: 
Component   Property   Time   System   Scale   Method
Hemoglobin A1c/Hemoglobin.total  MFr  Pt  Bld  Qn  HPLC
  Long Common Name:  Hemoglobin A1c/Hemoglobin.total in Blood by HPLC
  Short Name:  Hgb A1c MFr Bld HPLC
  Display Name:  HbA1c HPLC (Bld) [Mass fraction]

TERM DEFINITION/DESCRIPTION(S)
  Changing from the property from Mass fraction to substance fraction has not effect on the meaning when the molecular weight of the numerator and the denominator are the same (for practical purposes). These terms had had a property of MFR in the past and we changed to SFR because we thought the LOINC community preferred SFR for HbA1c. But we mis understood the preference is to use the MFR variant- so we have changed back.
 
 

PART DEFINITION/DESCRIPTION(S)
  Part: Hemoglobin A1c
  Currently (2010), four standardization protocols exist for measuring Hgb A1c:

1. IFCC - designated as a Reference Method or RM (http://www.ifcchba1c.net/)
2. NGSP - the long standing protocol used in the US and most other countries since the DCCT study (http://www.ngsp.org/factors.asp)
3.JDS/JSCC - a protocol used in Japan, Spain and possibly other countries
4. Swedish - used in Sweden at least

Protocols 2-4 are known as Designated Comparison Methods (DCM) and have been connected to the Reference Method and each other through various regression equations.

Because of the high degrees of standardization within protocol it should no longer be necessary to specify a LOINC code with a method such as “HPLC”, “electrophoresis” or anything else. Analytical instruments will be designed so that an Hgb A1c result can be traced back to a specific standardization protocol, so the important distinction will be the standardization protocol as described above and which will be carried in the method field.

A meeting of instrument manufacturers (presumably including Japanese) in Milan, Italy, December 12, 2007, agreed (among other items) that:

-All manufacturers should implement worldwide the traceability to the IFCC reference system for Hgb -A1c.
-All new instruments sold after January 1st, 2011 will report (as a result of an Hgb A1c test) both SI (mmol/mol – no decimals) and NGSP derived units (percentage – one decimal), in agreement with the Consensus Statement.
-Note they only committed to supporting protocol (1) and (2)

Different countries are adopting the international harmonization recommendations in different ways. We have information from the NGSP that the US will continue to report only Hgb A1c/NGSP, with the unit percent – i.e., no change. In Great Britain, labs have already started to report all results both as Hgb A1c (NGSP) in % and Hgb A1c (IFCC) in mmol/mol. In Canada, they are awaiting a recommendation from an expert panel. Any of these measures could be reported in the same units, but the convention for the reporting Hgb A1c under the new IFCC protocol will be to use units of mmol/mol to avoid confusion between the DCCT/NGSP and the IFFCC protocol.

LOINC has defined 59261-8 (Hemoglobin A1c/Hemoglobin.total in Blood) by IFCC protocol.

These protocols produce different results when expressed in the same units. For example, the equivalent of Hgb A1c (NGSP) of 6.5% is Hgb A1c (IFCC) is 4.8%.

The NGSP web site (http://www.ngsp.org/factors.asp) suggests the use of alternate measures, such as glycated albumen, for patients with severe iron deficiency, dialysis patients, and those with SS SC CC because of over or under reading that can occur with these interferences. It also describes the effect of abnormal hemoglobins on results of HbA1c by instrument.
 
 

MAPPING GUIDANCE
  Description: We do not recommend using this term. All HbA1c tests in US and many other countries are standardized to use [LOINC: 4548-4] .
 
 

BASIC ATTRIBUTES
  Class/Type: HEM/BC/Lab
  CDISC Lab Test: Y
  Common Lab Results Rank: #215
  Common SI Lab Results Rank: #215
  Common Orders Rank: #50
  First Released in Version: 1.0l
  Last Updated in Version: 2.40
  Order vs. Obs.: Both
  Status: Active

SUBMITTER'S INFORMATION
  Submitted Units: %

MEMBER OF THESE PANELS     
  This section provides information about panels that contain this LOINC code.
  LOINC   Long Common Name  
  54037-7 HEDIS 2009 panel
  57820-3 HEDIS 2010 panel
  60442-1 HEDIS 2011 panel
  67767-4 HEDIS 2012 panel
  72199-3 HEDIS 2013 panel
  74234-6 HEDIS 2014 Value Sets
  75868-0 HEDIS 2015 Value Sets
  79544-3 HEDIS 2016 Value Sets
  82955-6 HEDIS 2017 Value Sets
  87625-0 HEDIS 2018 Value Sets
  90766-7 HEDIS 2019 Value Sets
  

PARTS

Part Type    Part No.  Part Name   
Component   LP16413-4  Hemoglobin A1c 
     Divisors   LP32069-4  Hemoglobin.total 
Property   LP6831-4  MFr   [Mass fraction] 
Time   LP6960-1  Pt   [Point in time (spot)] 
System   LP7057-5  Bld   [Blood] 
Scale   LP7753-9  Qn 
Method   LP6319-0  HPLC   [High pressure liquid chromatography (HPLC)] 
Fragments for synonyms   LP21089-5  Total 

LANGUAGE VARIANTS
  Chinese (CHINA)  (From: Regenstrief-generated full translation based on part translation provided by Lin Zhang, A LOINC volunteer from China)
 
  血红蛋白 A1c/​血红蛋白.总计:质量分数:时间点:全血:定量型:高效液相色谱分析法血红蛋白 A1c/​血红蛋白.总计:质量分数:时间点:全血:定量型:高效液相色谱分析法
  Dutch (NETHERLANDS)  (From: Regenstrief-generated full translation based on part translation provided by NVKC, Dutch Society for Clinical Chemistry and Laboratory Medicine, The Netherlands)
 
  hemoglobine A1c/​hemoglobine.totaal:massafractie:moment:bloed:kwantitatief:HPLChemoglobine A1c/​hemoglobine.totaal:massafractie:moment:bloed:kwantitatief:HPLC
  Estonian (ESTONIA)  (From: Regenstrief-generated full translation based on part translation provided by Estonian E-Health Foundation)
 
  Hemoglobiin A1c/​hemoglobiin.üld:MFr:Pt:B:Qn:HPLCHemoglobiin A1c/​hemoglobiin.üld:MFr:Pt:B:Qn:HPLC
  French (BELGIUM)  (From: Regenstrief-generated full translation based on part translation provided by Jean M. Prevost, MD, Biopathology)
 
  Hémoglobine A1c/​Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:HPLCHémoglobine A1c/​Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:HPLC
  French (CANADA)  (From: Regenstrief-generated full translation based on part translation provided by Canada Health Infoway Inc.)
 
  Hémoglobine A1c/​Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:HPLCHémoglobine A1c/​Hémoglobine.totale:Fraction de masse:Temps ponctuel:Sang:Quantitatif:HPLC
  French (FRANCE)  (From: ASIP Santé (Agence des systèmes d'information partagés de santé))
 
  Hemoglobin A1c/​Hemoglobin.total:MFr:Pt:Bld:Qn:HPLCHemoglobin A1c/​Hemoglobin.total:MFr:Pt:Bld:Qn:HPLCHémoglobine A1c/​hémoglobine totale [Fraction massique] Sang ; Numérique ; HPLC
  French (SWITZERLAND)  (From: CUMUL, Switzerland)
 
  Sg--hémoglobine A1c; fraction de l'hémoglobine; ; HPLC
  German (AUSTRIA)  (From: ELGA, Austria)
 
  Hämoglobin A1c
  German (GERMANY)  (From: Institute for Medical Documentation and Information (DIMDI))
 
  Hämoglobin A1c/​Hämoglobin.total:SFr:Pkt:Blut:Qn:HPLCHämoglobin A1c/​Hämoglobin.total:SFr:Pkt:Blut:Qn:HPLC
  German (SWITZERLAND)  (From: CUMUL, Switzerland)
 
  B--Hämoglobin A1c; Hämoglobinfraktion; HPLC
  Italian (ITALY)  (From: Regenstrief-generated full translation based on part translation provided by Consiglio Nazionale delle Ricerche)
 
  Emoglobina A1c/​Emoglobina.totale:MFr:Pt:Sangue:Qn:HPLCEmoglobina A1c/​Emoglobina.totale:MFr:Pt:Sangue:Qn:HPLC
  Italian (SWITZERLAND)  (From: CUMUL, Switzerland)
 
  Sg--emoglobina A1c; frazione dell'emoglobina; ; HPLC
  Korean (KOREA, REPUBLIC OF)  (From: Korean Ministry for Health, Welfare, and Family Affairs)
 
  혈색소 A1C/​총혈색소:질량분획:검사시점:전혈:정량:고속 액체 크로마토그래피혈색소 A1C/​총혈색소:질량분획:검사시점:전혈:정량:고속 액체 크로마토그래피
  Portuguese (BRAZIL)  (From: HL7 Brazil Institute)
 
  Hemoglobina A1c/​Hemoglobina.total:SFr:Pt:SgTotal:Qn:Cromatografia de alta pressão líquidaHemoglobina A1c/​Hemoglobina.total:SFr:Pt:SgTotal:Qn:Cromatografia de alta pressão líquida
  Russian (RUSSIAN FEDERATION)  (From: Regenstrief-generated full translation based on part translation provided by Yaroslavl State Medical Academy)
 
  Гемоглобин А1с/​Гемоглобин.общий:МассДол:ТчкВрм:Кр:Колич:Высокое давление жидкостная хроматографияГемоглобин А1с/​Гемоглобин.общий:МассДол:ТчкВрм:Кр:Колич:Высокое давление жидкостная хроматография
  Spanish (ARGENTINA)  (From: Conceptum Medical Terminology Center)
 
  hemoglobina A1c/​hemoglobina.total:fracción de masa:punto en el tiempo:sangre:cuantitativo:cromatografía líquida de alto rendimientohemoglobina A1c/​hemoglobina.total:fracción de masa:punto en el tiempo:sangre:cuantitativo:cromatografía líquida de alto rendimiento
  Spanish (SPAIN)  (From: Regenstrief-generated full translation based on part translation provided by the Clinical Laboratory Committee of SERVICIO EXTREMEÑO DE SALUD, with the support of BITAC MAP.)
 
  Hemoglobina A1c (Hemoglobina glicosilada)/​Hemoglobina.total:Fracción de masa:Punto temporal:Sangre:Qn:Cromatografía líquida de alta presiónHemoglobina A1c (Hemoglobina glicosilada)/​Hemoglobina.total:Fracción de masa:Punto temporal:Sangre:Qn:Cromatografía líquida de alta presión
  Spanish (SWITZERLAND)  (From: CUMUL, Switzerland)
 
  Sg--hemoglobina A1c; fracción de la hemoglobina; ; HPLC
  Turkish (TURKEY)  (From: Regenstrief-generated full translation based on part translation provided by LOINC Turkish Translation Group and the Turkish Ministry of Health)
 
  Hemoglobin A1c/​Hemoglobin.total:KütlFr:Zmlı:Kan:Kant:HPLCHemoglobin A1c/​Hemoglobin.total:KütlFr:Zmlı:Kan:Kant:HPLC

RELATED NAMES
  Blood HEMATOLOGY/CELL COUNTS Quant
  GHb Hgb Quantitative
  Glycated hemoglobin Hgb A1c Random
  Glycohaemogolobin High performance liquid chromatography Tot
  Glycohemogolobin High pressure liquid chromatography Totl
  Glycosylated hemoglobin Mass Fraction WB
  HA1c Percent Whole blood
  Haemoglobin Point in time  
  Hb QNT  
  HbA1c Quan  

EXAMPLE UNITS
  Unit  Source Type
  EXAMPLE UCUM UNITS 
  ORIGINAL SUBMISSION 
  REGENSTRIEF 
  % Hgb  REGENSTRIEF 

UNITS (INTERNAL DETAILS)
  Source Type:  EXAMPLE UCUM UNITS 
  Unit: 
  Source Type:  ORIGINAL SUBMISSION 
  Unit: 
  Source Type:  REGENSTRIEF 
  Unit: 
  Source Type:  REGENSTRIEF 
  Unit:  % Hgb 

CHANGE HISTORY
  Change Type: MIN

INTERNAL FIELDS
  Detail Page Created On: 6/26/2019 7:14:33 PM
  Attachment Units Required: Y
  Long Common Name: Hemoglobin A1c/Hemoglobin.total in Blood by HPLC
  Shortname: Hgb A1c MFr Bld HPLC
  Fully Specified Name: Hemoglobin A1c/Hemoglobin.total: MFr: Pt: Bld: Qn: HPLC
     
  Component Word Count: 4
  ID: 8685
  Status (Raw): ACTIVE