Version 2.77

Part Description

LP263522-7   Clostridioides difficile BI-NAP1-027 strain
Clostridium difficile (CD) infections in hospitals across the United States, Canada and Europe experienced an enormous increase between 2000 and 2006. The pathogen that was found to cause this outbreak was the strain of CD determined by restriction endonuclease analysis (REA) to be toxin type III, restriction endonuclease analysis (REA) group B1; by pulsed-field gel electrophoresis as North American pulsed-field type NAP1; and by polymerase chain reaction (PCR) ribotyping as type 027. The strain is identified as Clostridium difficile BI/NAP1/027 or NAP1. The NAP1 strain of CD produces increased levels of three toxins, the usual toxins A and B, and a binary toxin. A mutation of the toxin A and B suppressor gene tcdC may explain the increased production of toxin. It is also strongly resistant to treatment with fluoroquinolone antibiotics. CD NAP1 is not a new strain of CD. It was isolated between 1984 and 1992 and is identical to the strain isolated is the 2000s, except that the original CD NAP1 strain was not resistant to the new fluoroquinolone drugs of the time, which included gatifloxacin and moxifloxacin. Risk factors for infection with CD NAP1 include advanced age, hospitalization, and exposure to antibiotics, notably fluoroquinolones and cephalosporins. The elderly are especially vulnerable to infection, and have a 30-day mortality rate of more than 5%. PMID: 19457419 Source: Regenstrief LOINC

Fully-Specified Name

Component
Clostridioides difficile BI-NAP1-027 strain DNA
Property
PrThr
Time
Pt
System
Stool
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
C diff BI NAP1 027 DNA Stl Ql NAA+probe
Display Name
C. difficile BI-NAP1-027 strain DNA NAA+probe Ql (Stl)
Consumer Name Alpha Get Info
Clostridioides difficile BI-NAP1-027 strain, Stool

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.63
Last Updated
Version 2.73
Change Reason
Updated genus name from Clostridium to Clostridioides based on current (2019) accepted nomenclature for this genus [PMID:27370902].
Order vs. Observation
Both
Common Test Rank Get Info
13281

Member of these Panels

LOINC Long Common Name
95183-0 Clostridioides difficile toxin and BI-NAP1-027 strain DNA panel - Stool by NAA with probe detection

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Clostridium diff. DNA (RT-027-Stamm) /ST ql. PCR
es-ES Spanish (Spain) Cepa BI-NAP1-027 Clostridium difficile ADN:PrThr:Punto temporal:Heces:Ord:Sonda con amplificación dirigida
es-MX Spanish (Mexico) ADN de la cepa de Clostridioides difficile BI-NAP1-027:Presencia o umbral:Punto temporal:Heces:Ordinal:Amplificación de ácidos nucleicos con detección de sonda
fr-FR French (France) Clostridioides difficile souche BI-NAP1-027 ADN:Présence/Seuil:Ponctuel:Selle:Qualitatif:PCR amplification de cible
it-IT Italian (Italy) Clostridium difficile BI-NAP1-027, variante DNA:PrThr:Pt:Feci:Ord:Sonda.amp.tar
Synonyms: Microbiologia Presenza o Soglia Punto nel tempo (episodio) Sonda con amplificazione Sonda con amplificazione del target Sonda di DNA Variante clostridium difficile BI-NAP1-027
zh-CN Chinese (China) 艰难梭菌 BI-NAP1-027 株 DNA:存在情况或阈值:时间点:大便:序数型:探针法.基因扩增.靶向
Synonyms: 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 便;大肠运动;排便;粪便;肠运动 借助扩增的探针方法;借助扩增的探针法;探针法.扩增 借助靶向扩增的探针方法;借助靶向扩增的探针法;探针法.扩增.靶向 去氧核糖核酸;脱氧核糖核酸 去氧核糖核酸;脱氧核糖核酸;脱氧核糖核酸（Deoxyribonucleic acid，DNA） 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 扩增型 扩增性 时刻;随机;随意;瞬间 经过扩增的 脱氧核糖核酸探针 艰难梭状芽胞杆菌;艰难芽孢梭菌 艰难梭菌（艰难梭状芽胞杆菌、艰难芽孢梭菌） BI-NAP1-027 株（菌株、分离株）

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=87755-5