Version 2.77

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP34979-2   Zinc finger protein of the cerebellum 4
Paraneoplastic neurological syndrome (PNS) is an autoimmune disorder that is manifested by progressive central, peripheral and/or autonomic nervous system symptoms. The neurological symptoms include encephalitis, autonomic failure, peripheral neuropathy, cerebellar ataxia, visual complaints and more. The antibodies that attack the neural tissue develop in response to tumor cells. The neoplasm may or may not be detectable using conventional imaging modalities. Since PNS can be associated with multiple antibodies testing usually includes a panel of PNS antibodies. In addition, the different PNS antibodies are associated with certain cancers so the antibody pattern can assist in identifying the specific tumor if it was previously undiagnosed. PMID: 22412264 Of patients positive for the zinc finger protein of the cerebellum 4 (Zic4) antibodies, ninety-two percent were diagnosed with small cell lung cancer. Zic4 antibodies often occur concurrently with Hu and CRMP5 antibodies. PMID: 15007130 Source: Regenstrief LOINC

Fully-Specified Name

Component
Zinc finger protein of the cerebellum 4 Ab.IgG
Property
PrThr
Time
Pt
System
Ser/Plas
Scale
Ord
Method
Line blot

Additional Names

Short Name
Zic4 IgG SerPl Ql Line blot
Display Name
Zinc finger protein of the cerebellum 4 IgG Line blot Ql
Consumer Name Alpha Get Info
Zinc finger protein of the cerebellum 4 IgG antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Proteína dedo de zinc del cerebelo 4 IgG:PrThr:Punto temporal:Suero o Plasma:Ord:Line blot
es-MX Spanish (Mexico) Proteína de dedos de zinc del cerebelo 4 Ab.IgG:Presencia o umbral:Punto temporal:Suero o Plasma:Ordinal:Mancha de línea
fr-CA French (Canada) Protéine à doigt de zinc du cervelet 4 , IgG:Présence-Seuil:Temps ponctuel:Sérum/Plasma:Ordinal:Immunoessai sur bandelette
fr-FR French (France) Zic4 anticorps IgG:Présence/Seuil:Ponctuel:Sérum/Plasma:Qualitatif:Blot en ligne
it-IT Italian (Italy) Zinc finger, proteina del cervelletto 4 Ab.IgG:PrThr:Pt:Siero/Plasma:Ord:Line blot
Synonyms: anticorpi IgG anticorpo Plasma Presenza o Soglia Proteina zinc finger del cervelletto 4 Punto nel tempo (episodio) Siero Siero o Plasma Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) zinc finger proteïne of the cerebellum 4 As.IgG:aanwezigheid:moment:serum of plasma:ordinaal:lijnblot
Synonyms: antistof; antilichaam
zh-CN Chinese (China) 小脑锌指蛋白 4 抗体.IgG:存在情况或阈值:时间点:血清/血浆:序数型:线点印迹法
Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 Zic4;小脑锌指蛋白 4;Zinc finger protein of the cerebellum 4 Zn 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 小脑锌指蛋白 4 Ab 时刻;随机;随意;瞬间 线点杂交技术;线点杂交法;线条状印迹法 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类 血清或血浆

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=83002-6