82994-5
MDA5 IgG Ab [Presence] in Serum by Line blot
Active
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
Part Descriptions
LP220403-2 MDA5
MDA5, more formally known as interferon-induced helicase C domain-containing protein 1, is an immune receptor for viral nucleic acids and plays a major role in activating antiviral responses, including the induction of type I interferons and proinflammatory cytokines. Anti-MDA5 autoantibodies, also known as anti-CADM-140, are associated with autoimmune disorders including dermatomyositis and interstitial lung disease. [UniProt: Q9BYX4] Anti-MDA5 autoantibodies are also found in a subset of patients with juvenile dermatomyositis (JDM) who have polyarthritis and ulcerative skin disease but milder muscle disease. Anti-MDA5 assays may be useful during the work-up of patients with inflammatory disorders and may help guide treatment. PMID: 24989778
Source: Regenstrief LOINC, PMID: 24989778
LP230511-0 MDA5 Ab.IgG
Melanoma differentiation-associated gene 5 (MDA5) senses intracellular pathogens. Through a complex cascade of intracellular interactions with a myriad of activators and regulators MDA5 contributes to the production of interferon-alpha and pro-inflammatory chemokines and cytokines. Antibodies to MDA5 have been linked to a subtype of dermatomyositis (DM) associated with low-grade to absent muscle inflammation, acute skin manifestations, hyperferritinemic status, frequent and rapidly progressive interstitial lung disease (ILD) and a poor prognosis.( https://clinicalmolecularallergy.biomedcentral.com/articles/10.1186/s12948-015-0031-y)
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- MDA5 Ab.IgG
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- Line blot
Additional Names
- Short Name
- MDA5 IgG Ser Ql Line blot
- Display Name
- MDA5 IgG Line blot Ql (S)
- Consumer Name Alpha Get Info
- MDA5 IgG antibody, Blood
Example Answer List: LL360-9
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.66
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
- Both
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | MDA5 IgG: |
| es-MX | Spanish (Mexico) | MDA5 Ab.IgG: |
| fr-FR | French (France) | MDA5 anticorps IgG: |
| it-IT | Italian (Italy) | MDA5 Ab.IgG: Synonyms: anticorpi IgG anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | MDA5 As.IgG: Synonyms: antistof; |
| zh-CN | Chinese (China) | MDA5 抗体.IgG: Synonyms: Ab.IgG; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=82994-5
Third Party Copyright
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Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright