Version 2.77

Term Description

This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC

Part Description

LP16719-4   Jo-1 extractable nuclear
Aminoacyl-tRNA synthetases (ARS) are enzymes that link amino acids to tRNA molecules and therefore play a key role in protein synthesis. Each ARS is specific for a single amino acid. [NCBI Books: NBK22356] Autoantibodies to ARS are a hallmark of connective tissue diseases including anti-synthetase syndrome (ASS) and idiopathic inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). ASS, PM and DM have overlapping features, including myositis, arthralgia, skin manifestations and interstitial lung disease. Antibodies to several specific ARS enzymes have been identified, including anti-histidyl (anti-Jo-1), anti-threonyl (anti-PL-7), anti-alanyl (anti-PL-12), anti-glycyl (anti-Ej), anti-isoleucyl (anti-Oj), anti-asparaginyl (anti-Ks), anti-phenylalanyl (anti-Zo), and anti-tyrosyl (anti-Ha). Different antibodies or patterns of antibodies have been associated with specific clinical features. Anti-Jo-1, anti-Ej, and anti-PL-7 antibodies are associated with myositis, including classic DM, clinically amyopathic DM (CADM) and PM. Anti-PL-12 alone is associated with CADM or interstitial lung disease (ILD). Anti-Ej and anti-PL-12 together are associated with CADM. Anti-Ks and anti-Oj are associated with ILD alone. PMID: 23573256 Anti-Ha and anti-Zo antibodies are the most recent autoantibodies to be identified in patients with symptoms of ASS. PMID: 17392287 Identifying the particular anti-ARS antibodies associated with an individual patient's disease may help guide treatment and predict clinical outcomes. Source: Regenstrief LOINC, PMID: 23573256

Fully-Specified Name

Component
Jo-1 extractable nuclear Ab.IgG
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Line blot

Additional Names

Short Name
ENA Jo1 IgG Ser Ql Line blot
Display Name
Jo-1 extractable nuclear IgG Line blot Ql (S)
Consumer Name Alpha Get Info
Jo-1 extractable nuclear IgG antibody, Blood

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.58
Last Updated
Version 2.66
Change Reason
This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
Order vs. Observation
Both

Member of these Groups Get Info

LOINC Group Group Name
LG17624-4 Jo-1 extractable nuclear Ab.IgG|PrThr|Pt|ANYBldSerPl

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Jo-1 IgG:PrThr:Punto temporal:Suero:Ord:Line blot
es-MX Spanish (Mexico) Ab.IgG nuclear extraíble con Jo-1:Presencia o umbral:Punto temporal:Suero:Ordinal:Mancha de línea
fr-CA French (Canada) Jo-1 nucléaire soluble , IgG:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:Immunoessai sur bandelette
fr-FR French (France) Jo-1 anticorps IgG:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Blot en ligne
it-IT Italian (Italy) Jo-1, nucleare estraibile Ab.IgG:PrThr:Pt:Siero:Ord:Line blot
Synonyms: anticorpi IgG anticorpo ENA Jo1 Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) jo-1 extraheerbaar nucleair As.IgG:aanwezigheid:moment:serum:ordinaal:lijnblot
Synonyms: antistof; antilichaam
pl-PL Polish (Poland) Jo-1 rozpuszczalny jądrowy Ab.IgG:granica wykrywalności:punkt w czasie:surowica:półilościowy:line blot
Synonyms: IgG Jo-1 rozpuszczalny jądrowy Przeciwciała do rozpuszczalnego antygenu jądrowego Przeciwciała do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała IgG do jądra komórkowego Przeciwciała IgG do rozpuszczalnego jądrowego antygenu Jo-1 Przeciwciała przeciwjądrowe
zh-CN Chinese (China) Jo-1 可提取性核 抗体.IgG:存在情况或阈值:时间点:血清:序数型:线点印迹法
Synonyms: Ⅰ Ab.IgG;IgG;抗体 IgG Ab;自身抗体 ANA ENA Ab ENA Jo1 Ab ENA Jo-1 Ab ENA Jo1 Ab.IgG ENA Jo-1 Ab.IgG ENA Jo1 IgG ENA Jo-1 IgG ENA Jo1 抗体 ENA Jo-1 抗体 ENA Jo1 抗体.IgG ENA Jo-1 抗体.IgG ENA Jo1;ENA Jo-1;Jo-1 可提取性核 Ag;Jo-1 可提取性核抗原;可提取性核 Ag Jo1;可提取性核 Ag Jo-1;可提取性核抗原 Jo1;可提取性核抗原 Jo-1;组氨酰-tRNA 合成酶;组氨酰基-tRNA 合成酶 ENA 抗体 ENA;可提取性核 Ag;可提取性核抗原;可提取性核抗原(Extractable Nuclear Antigen,ENA);可提取性细胞核;可提取性细胞核 Ag;可提取性细胞核抗原;盐水可提取性核 Ag;盐水可提取性核抗原;盐水可提取性细胞核 Ag;盐水可提取性细胞核抗原 I Jo1 可提取性核 Ab Jo-1 可提取性核 Ab Jo1 可提取性核 Ab.IgG Jo-1 可提取性核 Ab.IgG Jo1 可提取性核 Ag Ab Jo-1 可提取性核 Ag Ab Jo1 可提取性核 Ag Ab.IgG Jo-1 可提取性核 Ag Ab.IgG Jo1 可提取性核抗体 Jo1 可提取性核抗体.IgG Jo1 可提取性核抗原 抗体 Jo-1 可提取性核抗原 抗体 Jo1 可提取性核抗原 抗体.IgG Jo-1 可提取性核抗原 抗体.IgG NA 依次型;分类顺序型;定性的;序数型(或称等级型);性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫球蛋白 G 可提取性核 Ab 可提取性核 Ag Jo1 Ab 可提取性核 Ag Jo-1 Ab 可提取性核 Ag Jo1 Ab.IgG 可提取性核 Ag Jo-1 Ab.IgG 可提取性核 Ag 之 Ab 可提取性核抗原 Jo1 IgG 可提取性核抗原 Jo-1 IgG 可提取性核抗原 Jo1 抗体 可提取性核抗原 Jo-1 抗体 可提取性核抗原 Jo1 抗体.IgG 可提取性核抗原 Jo-1 抗体.IgG 可提取性核抗原之抗体 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况(存在、存在与否、是否存在)或阈值(界值、界限、阀值、临界值) 抗 ENA 抗可提取性核 Ag 抗可提取性核抗原 抗核 Ab 抗核抗体 抗核抗体(Antinuclear antibody,ANA) 时刻;随机;随意;瞬间 核;胞核 核心抗体IgG 核心抗原抗体.IgG 核心抗原抗体IgG 核抗体.IgG 核抗体IgG 核抗原抗体.IgG 核抗原抗体IgG 线点杂交技术;线点杂交法;线条状印迹法 细胞核 Ab 细胞核 Ab.IgG 细胞核 IgG 胞核 Ab 胞核 Ab.IgG 胞核抗体 胞核抗体.IgG 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目(非微生物学);血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验(非微生物学);血清学试验类 (非微生物学);血清类

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