82449-0
Titin Ab [Presence] in Serum by Line blot
Active
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
Part Description
LP220407-3 Titin
The titin protein plays a role in the assembly and functioning of striated muscles by connecting individual microfilaments, and may play a role in chromosome condensation and segregation during mitosis in non-muscle cells. [UniProt: Q8WZ42] Myasthenia gravis (MG) is an autoimmune disease mediated by antibodies against the acetylcholine receptor (AChR) in the postsynaptic membrane of the motor end plate, but antibodies against other targets, including titin, also play an important role. Anti-titin autoantibodies are also a sensitive marker for thymoma, which is often associated with MG, especially in patients with MG who are younger than 60 years old. PMID: 11405802
Source: Regenstrief LOINC, PMID: 11405802
Fully-Specified Name
- Component
- Titin Ab
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- Line blot
Additional Names
- Short Name
- Titin Ab Ser Ql Line blot
- Display Name
- Titin Ab Line blot Ql (S)
- Consumer Name Alpha Get Info
- Titin antibody, Blood
Example Answer List: LL360-9
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.73
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 18360
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG51428-7 | Titin Ab| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Titina Anticuerpos: |
| es-MX | Spanish (Mexico) | Titin Ab: |
| fr-FR | French (France) | Titine anticorps: |
| it-IT | Italian (Italy) | Titina Ab: Synonyms: anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| zh-CN | Chinese (China) | 肌巨蛋白 抗体: Synonyms: Ab; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=82449-0
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright