82447-4
Sulfatide IgM Ab [Presence] in Serum by Line blot
Active
Term Description
This term was created for, but is not limited in use to, the submitter's test strip, a membrane strip pre-coated with a specific set of antigens in parallel lines. If antibodies to any of those antigens are present in the patient's serum, they will bind to the specific antigen. The bound patient antibodies are then detected using labelled anti-human antibodies. Various manufacturers classify this method as an immunoblot technique. LOINC uses the immunoblot (IB) method to mean that some electrophoretic/chromatographic separation occurs such that position (size) of the band is part of the assessment (as in Western blot). Because this assay does not involve a separation step but rather uses strips with pre-fixed antigens, the LOINC Method is Line blot.
Source: Regenstrief LOINC
Part Description
LP14905-1 Sulfatide
Anti-sulfatide autoantibodies, also known as anti-GalS, have been associated with a variety of nervous system disorders, including IgM paraproteinaemia with associated demyelinating neuropathy, sensory impairment, and inflammatory demyelinating polyneuropathy (IDPN). Studies have shown the presence of GalS on the external surface of the myelin sheath, which suggests that anti-GalS auto-antibodies can induce immune demyelination and may play a role in the pathogenesis of motor neuropathies such as Guillain-Barre syndrome (GBS), and in fact, over 60% of GBS patients have been found to have anti-GalS antibodies. Some data show that patients presenting with high titer of anti-GalS antibodies could benefit from early treatment with plasmapheresis and/or intravenous immunoglobulin. PMID: 10762412 ]
Source: Regenstrief LOINC, PMID: 10762412
Fully-Specified Name
- Component
- Sulfatide Ab.IgM
- Property
- PrThr
- Time
- Pt
- System
- Ser
- Scale
- Ord
- Method
- Line blot
Additional Names
- Short Name
- Sulfatide IgM Ser Ql Line blot
- Display Name
- Sulfatide IgM Line blot Ql (S)
- Consumer Name Alpha Get Info
- Sulfatide IgM antibody, Blood
Example Answer List: LL360-9
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- SERO
- Type
- Laboratory
- First Released
- Version 2.58
- Last Updated
- Version 2.66
- Change Reason
- This term was created for an assay that uses a membrane strip pre-coated with a specific set of antigens in parallel lines. Because the antigens are seperated by electrophoresis/chromatographic separation during manufacturing, not during the test procedure itself, this test was assigned a LOINC Method of Immunoassay (IA) and not Immunoblot (IB). However, upon further review of IA, IB, and Immunoblot strip methodologies and regulatory distinctions between these, we changed the Method from IA to Line blot so that users can distinguish between these three Methods. The meaning of the term has not changed since it was created for an IB strip assay as described in the term description.
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG17829-9 | Sulfatide Ab.IgM| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Sulfátido IgM: |
| es-MX | Spanish (Mexico) | Ab.IgM de sulfatida: |
| fr-CA | French (Canada) | Sulfatide , IgM: |
| fr-FR | French (France) | Sulfatide anticorps IgM: |
| it-IT | Italian (Italy) | Sulfatide Ab.IgM: Synonyms: Anticorpi IgM anticorpo Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant |
| nl-NL | Dutch (Netherlands) | sulfatide As.IgM: Synonyms: antistof; |
| zh-CN | Chinese (China) | 硫酸脑苷脂 抗体.IgM: Synonyms: Ab.IgM; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=82447-4
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright