59585-0
GSTP1 gene+APC gene methylation [Presence] in Tissue by Molecular genetics method
Active
Term Description
GSTP1 and APC gene methylation are increase in prostate cancer.
Source: Regenstrief LOINC
Part Descriptions
LP100589-3 GSTP1 gene+APC gene methylation
The detection of methylated APC and GSTP1 DNA in serum correlated with the presence of CTC in the blood of breast cancer patients. Both methylated DNA and CTC correlated with a more aggressive tumor biology and advanced disease.
Source: NCBI PubMed, PubMed
LP124510-1 gene methylation
DNA methylation is essential during embryonic development, and patterns of DNA methylation are generally transmitted to daughter cells with a high fidelity. In cancer, aberrant DNA methylation patterns are found in two distinct forms: hypermethylation and hypomethylation. Hypermethylation is one of the major epigenetic modifications that repress transcription via the promoter region of tumor suppressor genes. Hypermethylation typically occurs at CpG islands in the promoter region and is associated with gene inactivation. Hypomethylation, linked to chromosomal instability and loss of imprinting, arises earlier and occurs throughout the progression of cancer.
More specifically, methylated DNA can bind to methyl-CpG-binding domain proteins (MBDs), which recruit additional proteins such as histone deacetylases and other chromatin remodeling proteins that modify histones to form compact, inactive chromatin, termed silent chromatin. Loss of methyl-CpG-binding protein 2 (MeCP2) has been implicated in Rett syndrome; and methyl-CpG-binding domain protein 2 (MBD2) mediates the transcriptional silencing of hypermethylated genes in cancer. Research has suggested that long-term memory storage in humans may be regulated by DNA methylation.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Wikipedia
Fully-Specified Name
- Component
- GSTP1 gene+APC gene methylation
- Property
- Arb
- Time
- Pt
- System
- Tiss
- Scale
- Ord
- Method
- Molgen
Additional Names
- Short Name
- GSTP1+APC gene methylation Tiss Ql
- Display Name
- GSTP1 gene+APC gene methylation Molgen Ql (Tiss)
- Consumer Name Alpha Get Info
- GSTP1 gene+APC gene methylation, Tissue
Example Answer List: LL360-9
Source: Regenstrief Institute| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 |
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.32
- Last Updated
- Version 2.73
- Order vs. Observation
- Both
- Common Test Rank Get Info
- 14411
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Metilación de gen GSTP1 + gen APC: |
| es-MX | Spanish (Mexico) | Metilación del gen GSTP1 + gen APC: |
| fr-FR | French (France) | GSTP1+APC gènes méthylation: |
| it-IT | Italian (Italy) | GSTP1, gene+gene APC, metilazione: Synonyms: Arbitrario Gene APC Genetica molecolare Metilazione di gene GSTP1+gene APC Patologia molecolare Punto nel tempo (episodio) Tessuto & |
| nl-NL | Dutch (Netherlands) | GSTP1-gen + APC-gen methylatie: Synonyms: APC gen GSTP1 gen+APC gen methylatie molgen |
| pt-BR | Portuguese (Brazil) | GSTP1 gene+APC gene metilação: |
| ru-RU | Russian (Russian Federation) | GSTP1 ген+APC ген метилирование: Synonyms: Порядковый Произвольный Ткань и мазки Точка во времени; |
| tr-TR | Turkish (Turkey) | GSTP1 geni+APC geni metilasyon: |
| zh-CN | Chinese (China) | GSTP1 基因+APC 基因甲基化: Synonyms: APC基因; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=59585-0
Third Party Copyright
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LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright